SPRIX Nasal Spray can be used for short-term treatment of moderate to severe pain for up to 5 days in adult patients who require opioid-strength pain relief.
SPRIX is delivered through a nasal spray. Each carton contains 5 bottles, with each bottle containing 8 precisely metered doses.
SPRIX is intended for use:
• Every 6-8 hours*
• Up to 4 times a day
• For up to 5 days, as needed
*For adult patients < 65 years of age, ≥ 110 lbs, and normal kidney function, the recommended dose is 1 spray in each nostril every 6-8 hours up to 4 times a day. For adult patients ≥ 65 years of age, renally impaired patients, and adult patients < 110 lbs, the recommended dose is 1 spray in 1 nostril every 6-8 hours up to 4 times per day.
How should I store SPRIX?
SPRIX is for use in the nose only. Do not breathe in (inhale) SPRIX.
Before you use SPRIX for the first time, you will need to prime the bottle. Hold the finger flange with your fingers (see Figure A), and remove the clear plastic cover with your opposite hand. Keep the clear plastic cover for later. Remove and throw away the blue plastic safety clip.
If the clear plastic cover is improperly removed, the tip of the bottle may be pulled off of the glass vial. If this happens, place the tip back onto the glass vial by lining it up carefully and gently pushing it back on until it is back in the correct position (see Figure B). The SPRIX bottle should work properly again.
Hold the SPRIX bottle upright at arm’s length away from you with your index finger on top of the finger flange and your thumb supporting the base (see Figure C).
Press down on the finger flange and release the pump 5 times. You may not see spray the first few times you press down. Now the pump is primed and ready to use. You do not need to prime the pump again if you use more doses from this bottle.
Blow your nose to clear your nostrils. Sit up straight or stand. Keep your head tilted downward toward your toes. Place the tip of the SPRIX bottle into your right nostril. Hold the SPRIX bottle upright and aim the tip toward the back of your nose (see Figure D).
Hold your breath and spray 1 time into your right nostril, pressing down on both sides of the finger flange (see Figure D). Breathe in gently through your mouth after you use SPRIX. You may also pinch your nose to help keep the medicine in your nose.
SPRIX is for use in the nose only. Do not breathe in (inhale) SPRIX.
If your healthcare provider has prescribed only 1 spray per dose for you, you have now finished your dose. However, if your healthcare provider has prescribed 2 sprays for you, repeat the above steps for your left nostril. Be sure to point the spray away from the center of your nose. Spray 1 time into your left nostril. When you are finished using SPRIX, put the clear plastic cover back on the SPRIX bottle.
SPRIX® Patient Use Video
IMPORTANT SAFETY INFORMATION ABOUT SPRIX®
Sprix (ketorolac tromethamine) Nasal Spray is an NSAID.
NSAIDs can cause serious side effects including, increased risk of a heart attack or stroke that can lead to death. This risk may happen early in treatment
and may increase with increasing doses of NSAIDs and with longer use of NSAIDs.
NSAIDs can also cause increased risk of bleeding, ulcers, and tears (perforation) of the esophagus (tube leading from the mouth to the stomach), stomach
and intestines which may occur anytime during use, without warning symptoms, and may cause death.
See the Boxed Warning: Risk of Serious Cardiovascular and Gastrointestinal Events
Do not take SPRIX right before or after a heart surgery called a “coronary artery bypass graft (CABG).”
Do not take SPRIX after a recent heart attack, unless your healthcare provider tells you to. You may have an increased risk of another heart attack if you
take NSAIDs after a recent heart attack.
The risk of getting an ulcer or bleeding also increases with:
SPRIX should only be used:
What is SPRIX ®?
SPRIX ® (ketorolac tromethamine) is used in adult patients for the short term (up to 5 days) management of moderate to moderately severe pain that requires analgesia at the opioid level.
Limitations of Use
Do not use SPRIX ®:
Before taking SPRIX or any NSAID, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all of the medicines you take, including prescription or over-the-counter medicines, vitamins or herbal supplements. SPRIX and some other medicines can interact with each other and cause serious side effects. Do not start taking any new medicine without talking to your healthcare provider first.
Other side effects of NSAIDs include: stomach pain, constipation, diarrhea, gas, heartburn, nausea, vomiting, and dizziness.
Most common side effects with SPRIX include: discomfort in the nose; pain in the nose; increased tears; throat irritation; decreased amount of urine;
rash; slow heart rate; increased liver enzymes; high blood pressure; stuffy nose.
Keep SPRIX away from your eyes. If you get SPRIX in your eyes, wash out the eye with water or saline, and call a doctor if irritation persists for more than
an hour.
These are not all the possible side effects of NSAIDs. For more information, ask your healthcare provider or pharmacist about NSAIDs.
Call your doctor for medical advice about side effects. You may report side effects to FDA at
IMPORTANT SAFETY INFORMATION ABOUT SPRIX®
Sprix (ketorolac tromethamine) Nasal Spray is an NSAID.
NSAIDs can cause serious side effects including, increased risk of a heart attack or stroke that can lead to death. This risk may happen early in treatment
and may increase with increasing doses of NSAIDs and with longer use of NSAIDs.
NSAIDs can also cause increased risk of bleeding, ulcers, and tears (perforation) of the esophagus (tube leading from the mouth to the stomach), stomach
and intestines which may occur anytime during use, without warning symptoms, and may cause death.
See the Boxed Warning: Risk of Serious Cardiovascular and Gastrointestinal Events
Do not take SPRIX right before or after a heart surgery called a “coronary artery bypass graft (CABG).”
Do not take SPRIX after a recent heart attack, unless your healthcare provider tells you to. You may have an increased risk of another heart attack if you
take NSAIDs after a recent heart attack.
The risk of getting an ulcer or bleeding also increases with:
SPRIX should only be used:
What is SPRIX ®?
SPRIX ® (ketorolac tromethamine) is used in adult patients for the short term (up to 5 days) management of moderate to moderately severe pain that requires analgesia at the opioid level.
Limitations of Use
Do not use SPRIX ®:
Before taking SPRIX or any NSAID, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all of the medicines you take, including prescription or over-the-counter medicines, vitamins or herbal supplements. SPRIX and some other medicines can interact with each other and cause serious side effects. Do not start taking any new medicine without talking to your healthcare provider first.
Other side effects of NSAIDs include: stomach pain, constipation, diarrhea, gas, heartburn, nausea, vomiting, and dizziness.
Most common side effects with SPRIX include: discomfort in the nose; pain in the nose; increased tears; throat irritation; decreased amount of urine;
rash; slow heart rate; increased liver enzymes; high blood pressure; stuffy nose.
Keep SPRIX away from your eyes. If you get SPRIX in your eyes, wash out the eye with water or saline, and call a doctor if irritation persists for more than
an hour.
These are not all the possible side effects of NSAIDs. For more information, ask your healthcare provider or pharmacist about NSAIDs.
Call your doctor for medical advice about side effects. You may report side effects to FDA at
